What Is The Difference Between Topoisomerase 1 And 2?

What Is The Difference Between Topoisomerase 1 And 2? The main difference between Topoisomerase I and II is that topoisomerase I cut one strand of the DNA double helix whereas topoisomerase II cut both strands of the DNA double helix. Furthermore, topoisomerase I do not require ATP hydrolysis while topoisomerase II requires ATP hydrolysis. What