What Do Focal Adhesions Do?
What Do Focal Adhesions Do? Focal adhesions anchor the cell to the substratum and can mediate both mechanical and biochemical signalling. What are the components of focal adhesions? Several components of focal adhesions (e.g., FAK, paxillin, p130Cas, etc.) are phosphorylated at specific tyrosine residues in response to integrin-mediated cell-ECM adhesion. In general, tyrosine phosphorylation can