Can A Blood Transfusion Affect Your Liver?

Can A Blood Transfusion Affect Your Liver? Hemochromatosis (iron overload): You can get too much iron in your blood if you have multiple blood transfusions. This can damage your heart and liver. Graft-versus-host disease: This complication is extremely rare, but is usually fatal. What are the side effects of having a blood transfusion? back pain.