Do Parietal Cells Secrete Histamine?

Do Parietal Cells Secrete Histamine? Parietal cells secrete acid in response to three types of stimuli: Histamine, stimulates H2 histamine receptors (most significant contribution). … Gastrin, stimulating CCK2 receptors (least significant contribution, but also causes histamine secretion by local ECL cells) Does the stomach secrete histamine? Gastric acid secretion Histamine plays an essential role in