glutathione overdose

Does Acetaminophen Affect Glutathione? Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro. What causes glutathione deficiency? Glutathione synthetase deficiency is caused by alterations (mutations) in the GSS gene and is inherited in an autosomal recessive manner. The generalized form is also known as 5-oxoprolinuria