Does Grapefruit Juice Interfere With Oxycodone?
Does Grapefruit Juice Interfere With Oxycodone? Grapefruit juice inhibited the CYP3A4-mediated first-pass metabolism of oxycodone, decreased the formation of noroxycodone and noroxymorphone and increased that of oxymorphone. We conclude that dietary consumption of grapefruit products may increase the concentrations and effects of oxycodone in clinical use. Can I drink grapefruit juice while taking oxycodone? Avoid