hyperpolarization

What Channels Open During Hyperpolarization? On hyperpolarization, HCN channels open and carry a Na+ inward current that in turn depolarizes the cell. They are modulated by cyclic nucleotides, and thereby, couple second-messenger signaling to electric activity (4). HCN channels, also known as pacemaker channels, serve diverse functions. What is happening during hyperpolarization? Hyperpolarization is when