What Are ISA Beta Blockers?

What Are ISA Beta Blockers? Intrinsic sympathomimetic activity (ISA) characterizes a group of beta blockers that are able to stimulate beta-adrenergic receptors (agonist effect) and to oppose the stimulating effects of catecholamines (antagonist effect) in a competitive way. Which beta-blocker has no ISA? Beta 1-selective drugs are also preferred in diabetic patients receiving hypoglycemic agents