Is Melasma Caused By Low Estrogen?

Is Melasma Caused By Low Estrogen? Answer: Melasma is typically caused in women by exposure to estrogens. For this reason, any hormone replacement you are taking that contains estrogen can contribute, so I would refrain from using estrogens. Does estrogen cause melasma? Hormones: Hormones like estrogen and progesterone may play a role in some people.