How Does Iron Deficiency Affect Erythropoiesis?
How Does Iron Deficiency Affect Erythropoiesis? Iron deficiency suppresses erythropoiesis by stimulating the IRP–HIF2α axis to reduce erythropoietin production, and by inhibiting aconitase-induced isocitrate activity to suppress early erythropoiesis. How does iron deficiency anemia affect erythropoiesis? Anemia with functional iron deficiency develops during increased erythropoiesis mediated either by endogenous erythropoietin responses to anemia, or by