intrinsic coagulation

What Triggers The Intrinsic Clotting Mechanism? The intrinsic pathway is activated by trauma inside the vascular system, and is activated by platelets, exposed endothelium, chemicals, or collagen. This pathway is slower than the extrinsic pathway, but more important. It involves factors XII, XI, IX, VIII. What activates the intrinsic clotting cascade? The contact pathway of