What Is The Difference Between Ionized And Unionized?

What Is The Difference Between Ionized And Unionized? Ionized molecules are usually unable to penetrate lipid cell membranes because they are hydrophilic and poorly lipid soluble. Unionized molecules are usually lipid soluble and can diffuse across cell membranes. What does it mean for a drug to be ionized? Ionized (or charged) drugs are not absorbed