Why Does Irinotecan Cause Diarrhea?

Why Does Irinotecan Cause Diarrhea? Irinotecan can cause acute diarrhea (immediately after drug administration) or delayed diarrhea. Immediate-onset diarrhea is caused by acute cholinergic properties and is often accompanied by other symptoms of cholinergic excess, including abdominal cramping, rhinitis, lacrimation, and salivation. How is irinotecan diarrhea treated? The recommended standard dose of loperamide is 4