How Does Isoniazid Cause B6 Deficiency?
How Does Isoniazid Cause B6 Deficiency? The isoniazid-induced peripheral neuropathy occurring in adult tuberculous patients results from a deficiency of biologically active pyridoxine. The deficiency is caused by the combination of isoniazid and pyridoxine to form a hydrazone which is excreted in the urine. How does isoniazid cause vitamin B6 deficiency? Second, INH inhibits the