What Enzyme Causes Jaundice?

What Enzyme Causes Jaundice? What enzyme causes jaundice? An inherited enzyme deficiency known as glucose 6 phosphate dehydrogenase (G6PD) could also lead to jaundice or kernicterus. What is the main cause of jaundice? Jaundice is often a sign of a problem with the liver, gallbladder, or pancreas. Jaundice can occur when too much bilirubin builds