Are Exotoxins Destroyed By Heat?

Are Exotoxins Destroyed By Heat? Most exotoxins can be destroyed by heating. They may exert their effect locally or produce systemic effects. (Nester, 2007). Well known exotoxins include the botulinum toxin produced by Clostridium botulinum, the Corynebacterium diphtheriae exotoxin which is produced during life threatening symptoms of diphtheria. Are exotoxins immunogenic? Exotoxins are highly immunogenic.