Can You Drink Grapefruit Juice With Methadone?

Can You Drink Grapefruit Juice With Methadone? Can you drink grapefruit juice with methadone? Exposure to substances like grapefruit juice, that inhibit these isoenzymes may result in increased blood levels of methadone, and thus may manifest clinically as unexpected opioid toxicity. Does grapefruit make methadone longer? Grapefruit juice led to a mean 17% increase in