Can You Take Antidepressants While On Methadone?
Can You Take Antidepressants While On Methadone? Can you take antidepressants while on methadone? Methadone has been associated with serotonin toxicity when given with other serotonergic medicines but the risk appears low. Methadone also has highly variable hepatic clearance via CYP3A4, CYP2B6 and CYP2D6. Most SSRIs and SNRIs inhibit one or more of these enzymes