Which Layer Of The Arterial Wall Does Atherosclerosis Primarily Affect?

Which Layer Of The Arterial Wall Does Atherosclerosis Primarily Affect? Atherosclerosis, the most common type, means hardening related to plaques, which are deposits of fatty materials. It affects medium-sized and large arteries. Arteriolosclerosis means hardening of the arterioles, which are small arteries. It affects primarily the inner and middle layers of the walls of arterioles.