How Does A Noncompetitive Inhibitor Reduce An Enzyme’s Activity?

How Does A Noncompetitive Inhibitor Reduce An Enzyme’s Activity? A noncompetitive inhibitor acts by decreasing the turnover number rather than by diminishing the proportion of enzyme molecules that are bound to substrate. Noncompetitive inhibition, in contrast with competitive inhibition, cannot be overcome by increasing the substrate concentration. What does a noncompetitive inhibitor do to an