How Does Neuroleptic Malignant Syndrome Happen?

How Does Neuroleptic Malignant Syndrome Happen? Neuroleptic malignant syndrome comes about, most likely, as a result of “dopamine D2 receptor antagonism”. Dopamine is a chemical substance (neurotransmitter) found in the brain and elsewhere in the central nervous system that acts to convey messages from one cell to another. Why do antipsychotics cause neuroleptic malignant syndrome?