Can Oranges Affect Medications?

Can Oranges Affect Medications? Can oranges affect medications? Yes. Grapefruit and certain other citrus fruits, such as Seville oranges, can interfere with several kinds of prescription medications. Don’t take these interactions lightly. Some can cause potentially dangerous health problems. What medications should not be taken with oranges? The allergy drug Allegra, available generically as fexofenadine.