Does Phenytoin Require TDM? Therapeutic drug monitoring of phenytoin is necessary to ensure therapeutic and nontoxic levels. Hypoalbuminemia, renal failure, and interactions with other highly protein-bound drugs (e.g., valproic acid) alter protein binding of phenytoin. Do you administer phenytoin on an empty stomach? This medicine can be taken with food or on an empty stomach.
How Do You Dilute IV Dilantin? For administration by intravenous infusion phenytoin injection should be diluted in 50 – 100 ml of normal saline, and the final concentration of phenytoin in the solution should not exceed 10 mg/ml, the infusion mixture should not be refrigerated. What IV solution is compatible with Dilantin? It is concluded
Why Is Phenytoin Given At Night? For example, if the delayed-action phenytoin is taken in the evening in place of ordinary phenytoin, it might be hoped that it would produce by the next morning higher blood and tissue concentrations of phenytoin than would the ordinary prepara- tion, thus reducing the risk of an early morning