Does PTH Inhibit Osteoblast Activity?

Does PTH Inhibit Osteoblast Activity? In contrast, when secreted continuously at relatively high doses (as seen in patients with pHPT), PTH stimulates osteoclast-mediated bone resorption and suppresses osteoblast activity. Does PTH stimulate osteoblasts? An increase in osteoblast differentiation rather than osteoblast proliferation appears to be the main mechanism by which PTH stimulates osteoblastogenesis. Indeed, PTH