What Is The Difference Between Peripheral And Central Sensitisation?
What Is The Difference Between Peripheral And Central Sensitisation? Peripheral sensitization is due to posttranslational and transcription changes in the terminal ends of high-threshold nociceptors resulting in primary hyperalgesia. Central sensitization in contrast typically manifests in tactile allodynia and secondary hyperalgesia (in tissue not affected by any harmful condition). How do you explain central sensitization?