Which Medicine Decrease Creatinine Level?

Which Medicine Decrease Creatinine Level? The antibiotic trimethoprim-sulfamethoxazole and the H2-blocker cimetidine are 2 commonly used drugs that decrease the secretion of creatinine. How do you decrease creatinine levels? Reducing your protein intake. Protein is an important nutrient needed by the body for various needs. … Increase your fibre intake. … Ensure you stay hydrated.