How Does Ristocetin Cofactor Assay Work? Ristocetin cofactor assay uses the patient’s platelet poor plasma (with vWF but no platelets) and adds ristocetin and exogenous formalin-fixed platelets which can passively agglutinate (but not actively aggregate, as they are dead). What is ristocetin cofactor assay? The Von Willebrand Ristocetin Cofactor [vWF:RCo] assay measures the ability of
How Does Ristocetin Cause Platelet Aggregation? In an unknown fashion, the antibiotic ristocetin causes von Willebrand factor to bind the platelet receptor glycoprotein Ib (GpIb), so when ristocetin is added to normal blood, it causes agglutination of fixed platelets or initiates the initial agglutination phase of aggregation of live platelets. What causes platelet aggregation? This
What Is Subendothelial? [ sŭb′ĕn-dō-thē′lē-əl ] n. The thin layer of connective tissue lying between the endothelium and elastic lamina in the intima of blood vessels. What does Subendothelial mean? Medical Definition of subendothelial : situated under an endothelium subendothelial tissues. Where is the subendothelial space? sub·en·do·the·li·al (sŭb’en-dō-thē’lē-ăl), Below the endothelium. What molecule on the