Can You Take Prednisone And Then Cycle Off?

Can You Take Prednisone And Then Cycle Off? Official Answer. It takes approximately 16.5 to 22 hours for Prednisone to be out of your system. The elimination half life of prednisone is around 3 to 4 hours. Can you take prednisone one day and then stop? When taken for extended periods, prednisone interferes with the