Can Dogs Take Oral Prednisone?

Can Dogs Take Oral Prednisone? Is it safe for dogs? Yes, Prednisone is safe for dogs, but like any medication, there are risks involved. Don’t use it for dogs who are allergic to it or dogs with viral infections, ulcers, tuberculosis, Cushing’s disease, or systemic fungal infections (unless it’s being used to treat Addison’s disease).