Can Prednisone Cause Internal Bleeding In Dogs?

Can Prednisone Cause Internal Bleeding In Dogs? Gastrointestinal bleeding and ulceration occur commonly in healthy dogs administered prednisone or prednisone/clopidogrel treatment, but not clopidogrel monotherapy. Though lesions are severe in many cases, they are not accompanied by clinical signs. What are the worst side effects of prednisone in dogs? Increased thirst and appetite. Frequent urination.