Can Antidepressants Increase Prolactin Levels?

Can Antidepressants Increase Prolactin Levels? It is some evidence that antidepressants that inhibit serotonin reuptake can increase the prolactin level. This adverse effect has been called serotonin overactivity. Selective serotonin-reuptake inhibitors (SSRIs) have been reported as the most common cause of drug-induced hyperprolactinemia. What medications raise prolactin levels? Antipsychotics (neuroleptics) Phenothiazines. Thioxanthenes. Butyrophenones. … Antidepressants.