How Often Maintenance Mercedes Benz S350 W221?

How Often Maintenance Mercedes Benz S350 W221? A Mercedes-Benz S-Class will cost about $12,306 for maintenance and repairs during its first 10 years of service. This is more than the industry average for luxury sedan models by $602. There is also a 31.57% chance that a S-Class will require a major repair during that time.