Why Is RNA More Vulnerable To Alkaline Hydrolysis Than DNA?
Why Is RNA More Vulnerable To Alkaline Hydrolysis Than DNA? RNA is susceptible to this base-catalyzed hydrolysis because the ribose sugar in RNA has a hydroxyl group at the 2′ position. This feature makes RNA chemically unstable compared to DNA, which does not have this 2′ -OH group and thus is not susceptible to base-catalyzed