How Is Sodium Involved In The Maintenance Of Acid-Base Balance?

How Is Sodium Involved In The Maintenance Of Acid-Base Balance? In addition, metabolic alkalosis can develop when excessive loss of fluids and electrolytes (such as sodium or potassium) affects the kidneys’ ability to maintain the blood’s acid-base balance. For instance, loss of potassium sufficient to cause metabolic alkalosis may result from an overactive adrenal gland.