Where Does Somatic Hypermutation Occur?
Where Does Somatic Hypermutation Occur? Somatic hypermutation (SHM) occurs in antigen-activated germinal center B cells and contributes to antibody affinity maturation (1–8). Where does somatic recombination occur? Somatic recombination occurs physiologically in the assembly of the B cell receptor and T-cell receptor genes (V(D)J recombination), as well as in the class switching of immunoglobulins. Somatic