How Is The Citric Acid Cycle Regulated?

How Is The Citric Acid Cycle Regulated? TCA cycle is regulated by allosteric regulation. The metabolites regulate the cycle by feedback inhibition. The enzyme isocitrate dehydrogenase and ⍺-ketoglutarate dehydrogenase are the main controlling point. ATP and NADH inhibit the enzymes isocitrate dehydrogenase and ⍺-ketoglutarate dehydrogenase. How is the citric acid cycle controlled? The citric acid