How Does Estrogen Affect The Bones?

How Does Estrogen Affect The Bones? Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. How does estrogen affect bone growth? During bone growth estrogen is needed for proper closure of epiphyseal growth