What Is A Non-inferiority Trial? A study that tests whether a new treatment is not worse than an active treatment it is being compared to. Non-inferiority trials are sometimes done when a placebo (an inactive treatment) cannot be used. How do you determine non-inferiority? In order to demonstrate non-inferiority, the recommended approach is to pre-specify
What Is A Superiority Trial? When the aim of the randomized controlled trial (RCT) is to show that one treatment is superior to another, a statistical test is employed and the trial (test) is called a superiority trial (test). Often a nonsignificant superiority test is wrongly interpreted as proof of no difference between the two
What Is An Inferiority Trial? Active control trials aim to demonstrate that treatments of interest have either superior effects or similar effects to the control. … If the intent of a study is to demonstrate that an experimental treatment is not substantially worse than a control treatment, the study is known as a noninferiority trial.