What Drug Is Tweek?

What Drug Is Tweek? What drug is tweek? Tweak, a slang name for methamphetamine. Tweaker, or alternate spelling tweeker, an individual addicted to methamphetamine. What does it mean to be tweaking? Slang. behaving in a wildly excited or agitated manner, especially as an effect of using methamphetamine, cocaine, or other stimulant drugs: He was pacing