What Causes Fever Without Infection?

What Causes Fever Without Infection? Rare causes of unexplained fevers include (but are not limited to) taking certain medications, adrenal disease, hematomas, hyperthyroidism, pulmonary emboli , and previously undetected thrombophlebitis. Despite extensive investigation, the cause of the fever is not identified in 5-15% of people with FUOs. Can you have a fever without an infection?