Why Is It More Difficult To Treat Eukaryotes And Viruses?

Why Is It More Difficult To Treat Eukaryotes And Viruses? Eukaryotic microbial pathogens can exhibit drug resistance through reducing the overall intracellular concentration of the drug (less uptake, more efflux), by inactivating or failing to activate the drug, or by sequestering the drug away from its target. Why is it harder to treat infections with