The chief cells secrete
pepsinogen
, a moderately sized zymogen protein with a molecular weight of 40,400. Pepsin, an enzyme with a molecular weight of 32,700, is formed in the acidic environment of the stomach when pepsinogen loses its activation peptides.
What hormone is produced by the chief cells quizlet?
Chief Cells. Releases pepsinogen which is then cleaved by HCl and turned into
pepsin
which can break down proteins. What type of digestion does HCl do?
What hormone is produced by chief cells?
Chief cells: The chief cells manage the secretion of
parathyroid hormone (PTH)
. When the cells are viewed, they contain prominent Golgi apparati and a developed endoplasmic reticulum to help with the synthesis and secretion of the hormone.
Do chief cells secrete hormones?
The parathyroid chief cell is the primary cell of the
parathyroid
gland. It produces and secretes parathyroid hormone in response to low calcium levels.
Which enzyme is produced by chief cells?
Pepsinogen
. Pepsinogen is a powerful and abundant protein digestive enzyme secreted by the gastric chief cells as a proenzyme and then converted by gastric acid in the gastric lumen to the active enzyme pepsin. The role of pepsin and its precursor in protein digestion was first described in the 19th century.
What is Chief cell and its function?
Chief cells are
responsible for secreting pepsinogen
. They have basally located nuclei and a basophilic cytoplasm with abundant rough endoplasmic reticulum and many secretory granules that contain pepsinogen. These are secreted into the lumen of the gastric gland.
What is produced by Enteroendocrine cells?
Enteroendocrine cells produce a range of
gut hormones
that have key roles in the coordination of food digestion and absorption, insulin secretion and appetite.
What must be present for a hormone to work?
A target cell responds to a hormone because it bears
receptors
for the hormone. In other words, a particular cell is a target cell for a hormone if it contains functional receptors for that hormone, and cells which do not have such a receptor cannot be influenced directly by that hormone.
What do chief cells secrete quizlet?
Chief cells secrete
Gastric Lipase
which functions to break down fats into smaller fatty acids that can be further digested in the intestine.
What do Oxyntic cells secrete?
Parietal cells (also called oxyntic cells) are the stomach epithelium cells which secrete
gastric acid
. Parietal cells produce gastric acid (hydrochloric acid) in response to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (gastrin receptors).
What does G cells secrete?
G-cells are neuroendocrine cells responsible for the synthesis and secretion of
gastrin
. They are primarily found in the pyloric antrum but can also be found in the duodenum and the pancreas. They secrete gastrin when stimulated directly by vagal efferent neurons as well as GRP neurons.
What do neck cells secrete?
HCl is necessary for the conversion of pepsinogen to pepsin. Mucous neck cells—Gastric glands in the upper part of the stomach contain mucous neck cells that secrete
thin, acidic mucus
that is much different from the mucus secreted by the goblet cells of the surface epithelium.
What does Enteroendocrine cells secrete?
Enteroendocrine cells produce a range of gut hormones that have key roles in the coordination of food digestion and absorption,
insulin secretion and appetite
.
At what pH is trypsin most effective?
The optimum temperature and pH for the trypsin are 65 °C and
pH 9.0
, respectively.
Do chief cells secrete hydrochloric acid?
Pepsin Pearls
Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen.
Parietal cells within the stomach lining
secrete hydrochloric acid that lowers the pH of the stomach.
What cell releases intrinsic factor?
Intrinsic factor is produced by
the gastric parietal cell
. Its secretion is stimulated via all pathways known to stimulate gastric acid secretion: histamine, gastrin, and acetylcholine.
