The chief cells secrete pepsinogen , a moderately sized zymogen protein with a molecular weight of 40,400. Pepsin, an enzyme with a molecular weight of 32,700, is formed in the acidic environment of the stomach when pepsinogen loses its activation peptides.
What hormone is produced by the chief cells quizlet?
Chief Cells. Releases pepsinogen which is then cleaved by HCl and turned into pepsin which can break down proteins. What type of digestion does HCl do?
What hormone is produced by chief cells?
Chief cells: The chief cells manage the secretion of parathyroid hormone (PTH) . When the cells are viewed, they contain prominent Golgi apparati and a developed endoplasmic reticulum to help with the synthesis and secretion of the hormone.
Do chief cells secrete hormones?
The parathyroid chief cell is the primary cell of the parathyroid gland. It produces and secretes parathyroid hormone in response to low calcium levels.
Which enzyme is produced by chief cells?
Pepsinogen . Pepsinogen is a powerful and abundant protein digestive enzyme secreted by the gastric chief cells as a proenzyme and then converted by gastric acid in the gastric lumen to the active enzyme pepsin. The role of pepsin and its precursor in protein digestion was first described in the 19th century.
What is Chief cell and its function?
Chief cells are responsible for secreting pepsinogen . They have basally located nuclei and a basophilic cytoplasm with abundant rough endoplasmic reticulum and many secretory granules that contain pepsinogen. These are secreted into the lumen of the gastric gland.
What is produced by Enteroendocrine cells?
Enteroendocrine cells produce a range of gut hormones that have key roles in the coordination of food digestion and absorption, insulin secretion and appetite.
What must be present for a hormone to work?
A target cell responds to a hormone because it bears receptors for the hormone. In other words, a particular cell is a target cell for a hormone if it contains functional receptors for that hormone, and cells which do not have such a receptor cannot be influenced directly by that hormone.
What do chief cells secrete quizlet?
Chief cells secrete Gastric Lipase which functions to break down fats into smaller fatty acids that can be further digested in the intestine.
What do Oxyntic cells secrete?
Parietal cells (also called oxyntic cells) are the stomach epithelium cells which secrete gastric acid . Parietal cells produce gastric acid (hydrochloric acid) in response to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (gastrin receptors).
What does G cells secrete?
G-cells are neuroendocrine cells responsible for the synthesis and secretion of gastrin . They are primarily found in the pyloric antrum but can also be found in the duodenum and the pancreas. They secrete gastrin when stimulated directly by vagal efferent neurons as well as GRP neurons.
What do neck cells secrete?
HCl is necessary for the conversion of pepsinogen to pepsin. Mucous neck cells—Gastric glands in the upper part of the stomach contain mucous neck cells that secrete thin, acidic mucus that is much different from the mucus secreted by the goblet cells of the surface epithelium.
What does Enteroendocrine cells secrete?
Enteroendocrine cells produce a range of gut hormones that have key roles in the coordination of food digestion and absorption, insulin secretion and appetite .
At what pH is trypsin most effective?
The optimum temperature and pH for the trypsin are 65 °C and pH 9.0 , respectively.
Do chief cells secrete hydrochloric acid?
Pepsin Pearls
Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach.
What cell releases intrinsic factor?
Intrinsic factor is produced by the gastric parietal cell . Its secretion is stimulated via all pathways known to stimulate gastric acid secretion: histamine, gastrin, and acetylcholine.
