For example, a CK7-negative/CK20-positive phenotype is often associated with
carcinomas of colorectal origin
, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.
Is CK7 positive cancer?
Clinical characteristics and findings. According to the criteria by Harbaum L [16], the immunoreactivity of CK7 was categorized as ‘negative’ (no tumor cells positive), ‘focal’ (<10% of tumor cells positive), ‘moderate’ (10-50%) or ‘extensive’ (>50%). Distinct
cytoplasmic immunoreactivity of CK7 was considered positive
…
What is CK7 positive CK20 positive?
Metastatic Tumors to Skin
CK7 is often positive in
upper gastrointestinal tract tumors such as gastric and duodenal carcinoma
. Colonic carcinomas, in contrast, are typically CK7(-)/CK20(+). This is metastatic gastric carcinoma, which first presented as a skin metastasis in an older adult patient.
What does CK7 test for?
CK7 distinguishes
between lung and breast epithelium that stain positive
, and colon and prostate epithelial cells that are negative. It also reacts with many benign and malignant epithelial lesions, e.g. adenocarcinomas of the ovary, breast and lung.
Is CK7 positive in squamous cell carcinoma?
CK5 is also highly specific for squamous cell carcinoma. Although CK20 positivity may be seen in pulmonary adenocarcinomas—in combination with negative staining for TTF1 and NAPA in rare cases—
CK7 is always positive.
Can melanoma be CK7 positive?
A. Of the above, CK7 is
the best screening marker for primary, extramammary Paget disease
. Sox10 would be positive in a melanocytic lesion (i.e. melanoma in situ), p63 positive in squamous cell carcinomas or primary adnexal neoplasms and uroplakin is positive in pagetoid urothelial intraepithelial neoplasia (PUIN).
Is carcinoma a cancer?
Carcinoma is
the most common type of cancer
. It begins in the epithelial tissue of the skin, or in the tissue that lines internal organs, such as the liver or kidneys. Carcinomas may spread to other parts of the body, or be confined to the primary location.
What is a CK7 marker?
Cytokeratin 7 (CK7) is a
type II basic low molecular weight cytokeratin
that is found in simple epithelia in a variety of organs, including all epithelia in the female genital tract.
305,306
. Epithelial tumors of the ovary and fallopian tube all exhibit cytoplasmic and/or membrane staining for CK7.
What does p63 positive mean?
P63: scored positive
when high intensity staining was present on ≥50% of tumor cells
; the remainder was scored negative [10]. TTF-1: scored positive when staining was present on ≥5% of tumor cells; the remainder was scored negative [11].
What is ttf1 positive?
Thyroid
transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas. This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours.
What is CK7 antibody?
CK7 antibody is
an intermediate filament protein (IFP) of 54 kDa
that recognizes the simple epithelium found in most glandular and transitional epithelia; but not in stratified squamous epithelia.
What does p40 positive mean?
P40, an isoform of p63 (deltaNp63), is a
highly sensitive and specific marker of SCC
. In previous reports, both the sensitivity and specificity of p40 for diagnosing pulmonary SCC have been almost 100%. 3-5 Thus, p40 is known as the best marker of this cancer.
What is CK7 in pathology?
CK7 is
a protein that is made mostly by cells
in the lung, breast, female reproductive organs (ovaries and endometrium), thyroid gland, and salivary glands (for example the parotid gland). It is also produced by some cells in the stomach and pancreas. CK7 is a type of protein called a keratin.
What is Napsin A?
Napsin A (Nap-A) is
a functional aspartic proteinase
that may be an alternative marker for primary lung ACA. Objectives: To compare Nap-A versus TTF-1 in the typing of primary lung carcinoma and the differentiation of primary lung ACA from carcinomas of other sites.
What is poorly differentiated squamous cell carcinoma?
Poorly-differentiated SCC’s are
known to grow rapidly, metastasis and can be highly recurrently
. If left untreated, SCCs may spread (metastasize) to local lymph nodes, distant tissues and organs and can become life-threatening. Treatment of metastatic SCC often include extensive surgery, radiotherapy and chemotherapy.
Is melanoma positive for cytokeratin?
The cytokeratin pattern of different tumour types, other than melanomas, is constant and assists in tumour progression from the very early stage up to late metastasis.
All melanomas are vimentin-positive in all cells
. Some melanomas are also reported to express cytokeratin.
