What drugs interact with baclofen?
- alcohol.
- antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- antidiabetes medications (e.g., glyburide, insulin)
What to avoid while taking baclofen?
baclofen food
You should
avoid or limit the use of alcohol
while being treated with baclofen. Do not use more than the recommended dose of baclofen, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you.
Is baclofen a strong muscle relaxer?
Baclofen is used to help relax certain muscles in your body
. It relieves the spasms, cramping, and tightness of muscles caused by medical problems, including multiple sclerosis or certain injuries to the spine.
Does baclofen help with nerve pain?
No. Baclofen is a muscle relaxer. While it can relieve pain due to muscle spasms,
it does not relieve pain due to other types of pain such as inflammatory or nerve pain
.
Is it OK to take baclofen and traMADol together?
baclofen traMADol
Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns.
Use separately: Your primary physician may offer you a prescription for pain medication and a muscle relaxant to help quell your symptoms.
Do not take both medications at the same time
.
Information from a research study shows an association of weight gain with the use of Baclofen
. It means that one of Baclofen side effects is weight gain. There was no observed change in the energy expended at rest, so one of Baclofen side effects, weight gain, may be linked to dietary intake.
- opioid drugs, such as the pain relievers OxyContin and Vicodin.
- benzodiazepines, a type of sedative medication such as Xanax and Klonopin.
- tricyclic antidepressants.
- monoamine oxidase inhibitors.
- fluvoxamine, a selective serotonin reuptake inhibitor.
- alcohol.
- CNS depressant drugs, such as opioids or psychotropics.
- sleeping medications.
- herbal supplements such as St. John’s wort.
Methocarbamol
. Methocarbamol works as a muscle relaxer by blocking pain sensations that reach the brain.
Generally,
cyclobenzaprine
is more effective in treating acute musculoskeletal pain due to an injury in the back or neck. Chronic pain from muscle spasticity related to neurological disease or injury responds best to baclofen.
The use of baclofen has also been shown to increase total sleep time
— both rapid eye movement (REM) and non-REM sleep duration — and has been associated with a significant reduction in the time spent awake after sleep onset.
For oral dosage form (tablets): Adults and teenagers—At first, 5 milligrams (mg) 3 times a day. Your doctor may increase your dose by 5 mg every 3 days until the desired response is reached. However, the dose is
not more than 80 mg per day
.
Baclofen exhibits anti-inflammatory
and neuroprotective activities: it inhibits the release of pro-inflammatory cytokines from microglia and astrocytes, and decreases oxidative stress in rats.
Baclofen is
not a narcotic
. It does not act on the opioid receptors in the brain. However, like opioids, it may be used to treat severe pain. It’s not a controlled substance.
Baclofen is absorbed quickly from the gastrointestinal tract, and peak concentration in the bloodstream occurs about 1-3 hours after oral administration of the medication. Baclofen’s half-life is 3-4 hours in plasma, and its shelf life is
three years from the date of manufacture
.
Combining Tramadol and Muscle Relaxers
Mixing Tramadol and these drugs is not a good idea
as both medicines are known to depress the central nervous system. The interaction also leads to other effects such as coma and respiratory distress.
2
Low doses of baclofen (less than 5 X 10(-8) mol), given intravenously, produced a transient fall in blood pressure and heart rate
. Higher doses (greater than 5 X 10(-7) mol) produced a marked and prolonged increase in blood pressure accompanied by a rise in heart rate and cutaneous arterial dilatation.
Interactions between your drugs
No interactions were found between baclofen and Paracetamol Arrow
. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
