Skip to main content

What Drugs Should Not Be Taken With Valtrex?

by
Last updated on 3 min read
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis and treatment. If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Valacyclovir and Valtrex should not be taken with cimetidine, elvitegravir/cobicistat/emtricitabine/tenofovir DF, emtricitabine, or tenofovir DF, as these combinations may increase blood levels of the antiviral medications and raise the risk of side effects.

Can I take vitamin D with valacyclovir?

No significant interactions have been found between vitamin D and valacyclovir, so they may typically be taken together safely.

That said, always run this combo past your doctor. Everyone’s health situation is different, and they can give you tailored advice. Vitamin D boosts immune function—pretty helpful when you're fighting a virus—but don’t guess on dosing. Follow your provider’s guidance. Got kidney issues? Mention it. Valacyclovir gets processed through your kidneys, so they’ll want to keep an eye on things. If you're curious about other medications that may interact with supplements, check out which supplements should not be taken during chemotherapy.

Can I take ibuprofen with Valtrex?

No clinically significant interactions have been identified between ibuprofen and Valtrex (valacyclovir), making this combination generally safe for most people.

Ibuprofen’s great for pain and swelling—common problems with infections like shingles or cold sores. Just don’t overdo it. Long-term or high-dose use can stress your kidneys, especially if they’re already compromised. Got nagging pain? Talk to your doctor about the safest way to manage it. For more on how drugs affect the body, see how long drugs can travel to the brain.

Should I take a probiotic with valacyclovir?

No known interactions prevent taking a probiotic with valacyclovir, so they can generally be taken together.

Antivirals can mess with your gut, so a probiotic might help keep things balanced. No red flags here, but spacing matters. Take your probiotic a couple hours away from your valacyclovir dose so both absorb properly. Look for strains like Lactobacillus or Bifidobacterium—they’re the gut-friendly MVPs. If you're exploring other medication interactions, learn about drugs that should not be taken with hydroxyzine.

Can you take vitamin D with acyclovir?

No significant interactions have been found between vitamin D and acyclovir, so they may be taken together safely.

Acyclovir treats herpes infections, and like valacyclovir, it’s processed by the kidneys. Vitamin D’s got immune-boosting perks, which could help during a viral flare-up. But don’t wing it on dosing—especially if your kidneys aren’t in top shape or you’re low on vitamin D. Run it by your doctor first. For more on mental health and substance use, explore whether drugs can cause a mental breakdown.

Edited and fact-checked by the FixAnswer editorial team.
James Park
Written by

James is a health and wellness writer providing evidence-based information on fitness, nutrition, mental health, and medical topics.

Is A Term Coined In 1972 By The Knapp Commission That Refers To Officers Who Engage In Minor Acts Of Corrupt Practices Eg Accepting Gratuities And Passively Accepting The Wrongdoings Of Other Officers?