Intravenous (IV) nicardipine (Cardene IV), which demonstrates a relatively rapid onset/offset of action, is used in
situations requiring the rapid control of blood pressure (BP)
. IV nicardipine was as effective as IV nitroprusside in the short-term reduction of BP in patients with severe or postoperative hypertension.
When do you use a cardene drip?
Intravenous (IV) nicardipine (Cardene IV), which demonstrates a relatively rapid onset/offset of action, is used in
situations requiring the rapid control of blood pressure (BP)
. IV nicardipine was as effective as IV nitroprusside in the short-term reduction of BP in patients with severe or postoperative hypertension.
How do you make a cardene drip?
Administer Cardene I.V.
by a central line or through a large peripheral vein
. Change the infusion site every 12 hours if administered via peripheral vein [see Intravenous Infusion Site].
Is cardene a vasopressor?
Position the patient so as to avoid cerebral anoxia. Use vasopressors for patients exhibiting profound hypotension. Cardene (nicardipine hydrochloride) is a
calcium ion influx inhibitor
(slow channel blocker or calcium channel blocker).
What kind of drug is cardene?
Nicardipine is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Nicardipine is called
a calcium channel blocker
. It works by relaxing blood vessels so blood can flow more easily.
How long does it take for nicardipine to work?
The onset of action is
1 to 2 minutes
and the half-life is approximately 40 minutes. Nicardipine is metabolized in the liver. Nicardipine can be started at a dose of 0.5 to 1 mcg/kg per minute and titrated to a maximum infusion rate of 3 mcg/kg per minute.
How do you wean off nicardipine drip?
Administration: Nicardipine (Cardene) 50 mg in 250 ml NS (0.2 mg/ml) starting at 5mg/hr (25 ml/hr) IV infusion. Titrate to effect by
increasing the rate of administration by 2.5 mg/hr every 5 minutes to a maximum of 15 mg/hr
until desired blood pressure reduction is achieved.
Does cardene cause bradycardia?
As a result, nicardipine
generally does not cause the atrioventricular
(AV) nodal blockade or bradycardia that is often de- scribed with nondihydropyridine calcium-channel blockers [3,4]. Experiments have demonstrated, however, that nicardipine can cause profound bradycardia when the sympathetic surge is blunted.
What are the side effects of nicardipine?
- headache.
- upset stomach.
- dizziness or lightheadedness.
- excessive tiredness.
- flushing.
- numbness.
- fast heartbeat.
- muscle cramps.
How do I start nicardipine drip?
Initial dose: Treatment should start with the continuous administration of
nicardipine at a rate of 3-5 mg/h for 15 minutes
. Rates can be increased by increments of 0.5 or 1 mg every 15 minutes. The infusion rate should not exceed 15 mg/h.
What is difference between dopamine and dobutamine?
Dopamine is typically used in the treatment of septic shock or cardiogenic shock. Dobutamine is a drug that primarily stimulates
beta-1
receptors, leading to increased inotropic and chronotropic effects. to al lesser extent, dobutamine also stimulates beta-2 adrenergic receptors, leading to vasodilatation.
What is the most common cause of hypertension in ICU patients?
Causes include:
Sympathomimetic drugs
(e.g. cocaine, over-the-counter decongestants) Other medications (e.g. cyclosporine, tacrolimus, erythropoietin, steroid, NSAIDs) CNS event (e.g. ischemic stroke, intracranial hemorrhage)
What is the difference between Cardene and Cardizem?
Cardene is a dihydropyridine calcium channel blocker and Cardizem is a
benzothiazepine
calcium channel blocker. The patient received the wrong medication for several hours and became hypotensive. Because the error was discovered and the patient quickly treated, the patient experienced no permanent harm.
Does cardene slow heart rate?
By slowing calcium influx into cardiac muscle cells, calcium channel blockers tend
to reduce the force of cardiac contraction
, thus reducing cardiac work and the vigor of the heart beat.
What are the side effects of precedex?
- low or high blood pressure (hypotension or hypertension),
- slow heart rate (bradycardia),
- nausea,
- dry mouth,
- irregular heartbeat,
- fever,
- vomiting,
- low blood plasma,
Are nimodipine and nicardipine the same?
Nicardipine (Cardene, Cardene SR) and nimodipine (Nimotop)
are similar to nifedipine
, although they demonstrate greater peripheral vascular smooth muscle effects. They may have small, negative inotropic effects. Nicardipine and nimodipine are predominantly metabolized by the liver.
