Examples of multifactorial traits and diseases include:
height, neural tube defects, and hip dysplasia
.
What is a multifactorial inheritance?
Multifactorial inheritance is
when more than one factor causes a trait or health problem
, such as a birth defect or chronic illness. The main factor is genes. But the cause includes other factors that aren’t genes, such as: Nutrition. Lifestyle.
What is an example of a multifactorial trait?
Examples of Multifactorial Traits:
Fingerprint patterns, height, eye color, and skin color
…
What is an example of a multifactorial genetic disorder?
In humans, there are many other disorders that show multifactorial inheritance patterns, such as
multiple sclerosis
, diabetes, asthma, cancer, and numerous birth defects.
Which is an example of a multifactorial polygenic trait?
For example,
height
is thought to be polygenically inherited, but a person’s stature also is significantly affected by adequacy of diet while growing. Cleft lip with or without cleft palate is probably an example of a polygenic trait with a threshold effect. Its incidence in the general population is about 1/1000.
What are 3 examples of polygenic traits?
In humans,
height, skin color, hair color, and eye color
are examples of polygenic traits.
Is Down Syndrome multifactorial?
Down syndrome genetics: unravelling
a multifactorial disorder
.
What is mitochondrial inheritance?
Unlike nuclear genes, which are inherited from both parents, mitochondrial genes
are inherited only from the mother
. If there is a mutation in a mitochondrial gene, it is passed from a mother to all of her children; sons will not pass it on, but daughters will pass it on to all of their children, and so on.
Is diabetes a multifactorial trait?
Type 2 diabetes is a
multifactorial disease
caused by both oligo- and polygenic genetic factors as well as non-genetic factors that result from a lack of balance between the energy intake and output and other life style related factors.
What are QTLS in genetics?
Quantitative trait locus
(QTL) analysis is a statistical method that links two types of information—phenotypic data (trait measurements) and genotypic data (usually molecular markers)—in an attempt to explain the genetic basis of variation in complex traits (Falconer & Mackay, 1996; Kearsey, 1998; Lynch & Walsh, 1998).
What are the genetic and environmental components of multifactorial inheritance?
Multifactorial inheritance means that “many factors” (multifactorial) are involved in causing a birth defect. The factors are usually
both genetic and environmental
, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition.
Is Marfan syndrome multifactorial?
Marfan syndrome is
an autosomal dominant disorder
. This means that each offspring of an affected parent will have a 50 percent chance of also being born with the disorder.
What is complex inheritance?
Complex Inheritance:
(inherited) traits that have a genetic component that does not follow strict Mendelian inheritance
. May involve the interaction of two or more genes or gene-environment interactions. ( HGPIA)
Is schizophrenia polygenic or multifactorial?
Schizophrenia is a
complex biological disorder with multifactorial mode of transmission
where non-genetic determinants are also play important role. It is now clear that it involves combined effect of many genes, each conferring a small increase in liability to the illness.
Why Is height a good example of polygenic inheritance?
Why is height a good example of polygenic inheritance?
because the characters vary in the population in gradients along a continuum
.
What is quantitative inheritance?
quantitative inheritance The inheritance of a character (known as a quantitative character or trait) that
depends upon the cumulative action of many genes
, each of which produces only a small effect.
Which of the following phenotypes is an example of a polygenic inheritance?
Polygenic traits have many possible phenotypes (physical characteristics) that are determined by interactions among several alleles. Examples of polygenic inheritance in humans include traits such as
skin color, eye color, hair color, body shape, height, and weight
.
Is autism hereditary?
ASD has a tendency to run in families, but
the inheritance pattern is usually unknown
. People with gene changes associated with ASD generally inherit an increased risk of developing the condition, rather than the condition itself.
Which is an example of co dominance?
Codominance means that neither allele can mask the expression of the other allele. An example in humans would be
the ABO blood group
, where alleles A and alleles B are both expressed. So if an individual inherits allele A from their mother and allele B from their father, they have blood type AB.
Which of the following phenotypes is an example of polygenic inheritance quizlet?
An example of polygenic inheritance in humans is
skin color
. The skin color is controlled by 1, 3, & 4 genes. You can tell that it is polygenic in a population by the people having different types of skin color. Many different phenotype.
What is the rarest birth defect?
- Muscular dystrophy.
- Osteogenesis imperfecta.
- Progeria.
- Smith Lemli Opitz syndrome.
- Spinal muscular atrophy.
- Tuberous sclerosis.
- Turner syndrome.
- X-linked lymphoproliferative syndrome (Duncan disease)
What is cat Down syndrome?
A so-called “Down syndrome cat” typically manifests some distinctive characteristics, including: Broad noses. Upturned eyes (which may be set widely apart)
Small or unusual ears
.
Low muscle tone
.
What is an example of a mitochondrial disease?
Examples of mitochondrial diseases include:
Leber’s hereditary optic neuropathy (LHON)
Chronic progressive external ophthalmoplegia (CPEO) Myoclonic epilepsy with ragged red fibres (MERRF)
Is mitochondrial DNA packaged with histones?
In contrast,
the mitochondrial genome lacks histones
, which has led to the belief that the observed high rate of mtDNA mutagenesis (∼10-fold greater than in nDNA) (Brown et al. … Moreover, mtDNA may be physically covered with TFAM, an HMG-like protein involved in mtDNA transcription and replication.
How are mitochondria inherited in humans quizlet?
The mitochondria are
only inherited through the sperm cells
. … Both male and female offspring receive their mitochondria from the mother.
Is t2dm inherited?
Type 2 diabetes does not have a clear pattern of inheritance
, although many affected individuals have at least one close family member, such as a parent or sibling, with the disease. The risk of developing type 2 diabetes increases with the number of affected family members.
How do you find QTLs?
The simplest approach for detecting QTLs is
to analyze the data one marker at a time
. If an association exists between a molecular marker genotype and trait value, a trait locus is likely to be near that marker locus. The advantage of single-marker mapping is that it works for any population structure.
What means phenotype?
A phenotype is
an individual’s observable traits, such as height, eye color, and blood type
. The genetic contribution to the phenotype is called the genotype. Some traits are largely determined by the genotype, while other traits are largely determined by environmental factors.
How does polygenic inheritance work?
Polygenic inheritance occurs
when one characteristic is controlled by two or more genes
. Often the genes are large in quantity but small in effect. Examples of human polygenic inheritance are height, skin color, eye color and weight.
Is Sickle Cell Anemia multifactorial?
Sickle Cell Disease as a
Multifactorial Condition
.
Is Alzheimer’s a multifactorial disorder?
Alzheimer’s disease (AD) is
a multifactorial neurodegenerative disorder
with several target proteins contributing to its aetiology.
What are the four types of complex inheritance?
- Incomplete Dominance.
- Codominance.
- Multiple Alleles.
- Polygenic Traits.
What is autosomal dominant inheritance?
Autosomal dominant inheritance is
a way a genetic trait or condition can be passed down from parent to child
. One copy of a mutated (changed) gene from one parent can cause the genetic condition. A child who has a parent with the mutated gene has a 50% chance of inheriting that mutated gene.
What is an example of a complex trait in humans?
Examples of complex traits include disorders such as
autism, cardiac disease, cancer, diabetes, Alzheimer’s disease, and asthma
. Complex traits are believed to result from gene-gene and gene-environment interactions, genetic heterogeneity, and potentially other yet unknown reasons.
Which of the following are examples of environmental effects on phenotype?
Environmental factors such as
diet, temperature, oxygen levels, humidity, light cycles
, and the presence of mutagens can all impact which of an animal’s genes are expressed, which ultimately affects the animal’s phenotype.
Is PP genotype or phenotype?
There are three available genotypes, PP (
homozygous dominant
), Pp (heterozygous), and pp (homozygous recessive). All three have different genotypes but the first two have the same phenotype (purple) as distinct from the third (white).
What are examples of single gene disorders?
Some of the more common single-gene disorders include
cystic fibrosis, hemochromatosis, Tay-Sachs, and sickle cell anemia
. Even though these diseases are primarily caused by a single gene, several different mutations can result in the same disease but with varying degrees of severity and phenotype.
Is progeria dominant or recessive?
Hutchinson-Gilford progeria syndrome is considered an
autosomal dominant condition
, which means one copy of the altered gene in each cell is sufficient to cause the disorder. The condition results from new mutations in the LMNA gene, and almost always occurs in people with no history of the disorder in their family.
How is Marfan inherited?
Marfan syndrome
is hereditary
, which means it can be passed to a child from a parent who’s affected. In around three-quarters (75%) of cases, Marfan syndrome is inherited from 1 parent. The syndrome is autosomal dominant, which means a child can inherit it even if only 1 parent has the syndrome.
What is it called when you have long fingers?
Arachnodactyly (“spider fingers”)
is a condition in which the fingers and toes are abnormally long and slender, in comparison to the palm of the hand and arch of the foot.
Is Huntington’s disease polygenic inheritance?
Huntington’s Disease
The disease is
inherited as an autosomal dominant trait
, meaning that a single mutated copy of the responsible gene is sufficient to cause the disease.
Is schizophrenia monogenic or polygenic?
In contrast to the initial monogenic and oligogenic models of genetic transmission, there is now compelling evidence that the genetic architecture of schizophrenia is
very complex, heterogeneous, and polygenic
—the disease risk is constituted by numerous common genetic variants of only very small individual effects ( …
Is Cystic Fibrosis polygenic?
These diseases have been categorized as “oligogenic” rather than
“polygenic
,” because they involve only a relatively small number of genes. For example, cystic fibrosis is typically characterized as a single-gene disease associated with recessive mutations in the CFTR gene.
