Geometric dilution is used
when blending two or more ingredients of unequal quantities
. The API is blended with excipients in equal proportions until all excipients have been thoroughly mixed.
What is significant about the geometric dilution process Why is it needed?
Why is it needed? The geometric dilution process is
the procedure undertaken to dilute something according to its quantified size
. It is important because scientists and doctors implement the procedure to make certain of equal distribution when combining unequal amounts of fine powders.
What is geometric dilution method?
When mixing a small amount of a drug with a large amount of another ingredient or diluent
, the process of geometric dilution is used. In this method the drug present in smaller quantity is placed in the mortar with an equal amount of the other ingredient. The two materials are triturated until they are well mixed.
Which method is used for mixing of powder?
Powder mixers (tumbling, convective, or high shear) are classified according to their mixing mechanism:
diffusion, convection, and shear
. The selection of the mixer depends on the particle characteristics, such as shape, particle size, density, and the amount of each component.
What is trituration method?
A trituration is
a dilution of a potent drug powder with an inert diluent powder, usually lactose
, in a definite proportion by weight. We can then remove a weighable portion (aliquot) of the mixture containing the desired quantity of substance to maintain an acceptable range of accuracy.
Which ointment base is the most effective occlusive dressing?
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Which method is used when potent substance is mixed with large amount of diluent?
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Geometric dilution:-
The method is used when potent substances are to mixed with a large amount of diluent. The potent drug is placed upon an approximately equal volume of the dilute in a mortar and the substances are slightly mixed by trituration.
Why granulation is required?
Granulation is a
key processing step in the production of many solid dosage drugs
. It is often necessary to convert powdered drug formulations into a physical form that has improved flow and compaction characteristics to produce tablets with uniform content and consistent hardness and other properties.
What is the difference between Levigation and trituration?
Trituration is the continuous rubbing or grinding of the powder in a mortar with a pestle. …
Levigation reduces the particle size by triturating it
in a mortar or spatulating it on an ointment slab or pad with a small amount of a liquid in which the solid is not soluble.
What is comminution in compounding?
Comminution is the
process of physical reduction of a substance to fine particle size
, which makes the substance or drug easier to dissolve and compound. The processes for comminution are cutting, grating, grinding, pulverizing, trituration, and levitation.
What are 5 types of mixing equipment?
- Tumbler Blender – for dry mixing. …
- Ribbon Blender – This mixer is for bulk solid and powder blending. …
- Paddle Mixer – For solids, wet-dry mixing, viscous/slurry liquid mixing. …
- Agitator – Liquid-liquid mixing or liquid-gas mixing. …
- Emulsifiers – for immiscible liquids.
What is geometric mixing of powders?
Geometric dilution is the
process of diluting something based on its measured size
. Most often, scientists and doctors employ this method when combining fine powders of unequal amounts to ensure equal distribution. Bakers sometimes use geometric dilution to equally combine the dry ingredients in a mixture.
What equipment is used for mixing?
Mixing equipment is useful in a large variety of laboratory applications and chemistry experiments. Our mixing equipment consists of three main categories which include
laboratory shakers, mixers and rockers
. Shakers are frequently used for sedimentation studies and some cell and tissue work.
How do you calculate trituration?
In a 1:10 trituration 10g of trituration contains 1g of drug. Since 50mg = 0.05g to obtain 50mg of the drug requires 0.05 × 10g = 0.5g of trituration. Example Calculate the amounts of the ingredients required to prepare five powders each containing 250micrograms (or mcg) of Digoxin.
What are the objectives of trituration procedure?
The objective of trituration is
to provide proper amalgamation of the mercury and alloy
. There is always an oxide layer of the alloy surface that hinders diffusion of mercury into the alloy. This film must be disrupted so that a clean surface of alloy can make intimate contact with the mercury.
What is Spatulation method?
spatulation – Spatulation is
the mixing of powders and semi-solids (ointments, creams, etc.) on an ointment pad or slab using a spatula
. … When using this method, the smallest quantity of active ingredient is mixed thoroughly with a proportion quantity of the diluent or base on the ointment slab.
