Initially introduced in tablet form during the late 1950s as the OTC cough suppressant Romilar, DXM has a long history of abuse. Because of diversion to recreational use, Romilar was removed from the OTC market in
1973
[5,6].
When was Romilar removed from the OTC market?
Initially introduced in tablet form during the late 1950s as the OTC cough suppressant Romilar, DXM has a long history of abuse. Because of diversion to recreational use, Romilar was removed from the OTC market in
1973
[5,6].
What kind of drug is dextromethorphan?
Dextromethorphan is in a class of medications called
antitussives
. It works by decreasing activity in the part of the brain that causes coughing.
Can dextromethorphan make you sleepy?
Slight drowsiness
/dizziness, nausea, or vomiting may occur. Rarely, some people may experience severe drowsiness/dizziness with normal doses. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
What is dextromethorphan HBR used for?
This medication is used for
temporary relief of coughs without phlegm
that are caused by certain infections of the air passages (e.g., sinusitis, common cold).
What happens if you take too much dextromethorphan?
Dangerous physical symptoms of dextromethorphan overdose include
tachycardia, slow breathing, changes in blood pressure and body temperature, and seizures
. It is important to get help for a person suffering from a DXM overdose before these symptoms begin because they are more likely to lead to coma or death.
Is dextromethorphan a stimulant or depressant?
DXM is an opioid without effects on pain reduction and does not act on the opioid receptors. When taken in large doses, DXM causes a
depressant effect
and sometimes a hallucinogenic effect, similar to PCP and ketamine.
What can you not take with dextromethorphan?
Do not use dextromethorphan if you have used
an MAO inhibitor
in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
How many days can you take dextromethorphan?
-Patients should be instructed to stop taking product and consult with their health care provider if cough lasts more than
7 days
, if it returns, or is accompanied by persistent fevers, rashes, or headaches, as it could be a sign of a more serious condition.
How long does it take dextromethorphan to start working?
The effects start to kick in
around 30 to 60 minutes
after taking DXM and reach their peak at 2 to 4 hours. Your dose, other ingredients, and your body mass index (BMI) can affect how quickly you begin to feel it.
How does dextromethorphan work in the body?
Dextromethorphan works on the
part of your brain responsible for the cough reflex
, disrupting the communication between your brain and the nerves which provoke the coughing. It temporarily blocks the “lock” so that the “key” no longer fits.
Why does dextromethorphan make me feel weird?
DXM also depresses brain function, particularly the parts of the brain that control breathing and heart function. Taking a lot of DXM
causes hallucinations and out-of-body sensations
similar to the ones caused by drugs like ketamine and PCP. These effects can last as long as 6 hours.
Does dextromethorphan HBR raise blood pressure?
It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.
These medicines are not known to elevate blood pressure
. The combination of dextromethorphan and guaifenesin is used to treat cough and chest congestion caused by the common cold, infections, or allergies.
Is dextromethorphan HBr a stimulant?
Dextromethorphan, often referred to as DXM, is a medication most often used as a cough suppressant in over-the-counter cold and cough medicines. It is sold in syrup, tablet, spray, and lozenge forms. It is in the morphinan class of medications with
sedative, dissociative, and stimulant properties
(at lower doses).
How effective is dextromethorphan?
Two out of three adult studies of dextromethorphan, including one meta-analysis of five studies, found a statistically significant benefit:
a 30-mg single dose was more effective than placebo in reducing cough symptoms
, as measured by cough counts, frequency, effort, and intensity.
What is a triple C trip like?
These are dosed in 2.5-10mg and are intended, in low doses, to reduce the effects of
congestion and coughing
. However, in large doses, they cause hallucinations, euphoria, auditory changes, and changes in sense of gravity. “High” users may describe sensations of floating and disassociation, like “living in a dream”.
